Pseudoexfoliation syndrome (PXS) is associated with increased risk of glaucoma, but the underlying molecular mechanisms remain unclear. This study aimed to compare microRNA (miRNA) expression profiles between PXS with glaucoma (PXSG) and PXS without glaucoma (PXSWG).
We enrolled 24 PXS patients undergoing cataract surgery, dividing them into PXSG (n=16) and PXSWG (n=8) groups. miRNA expression in anterior lens capsule tissue was analysed using NanoString nCounter technology. Differentially expressed miRNAs were identified, and functional pathway analysis was conducted using the Kyoto Encyclopedia of Genes and Genomes (KEGG). The correlations between miRNA expression and clinical variables, including glaucoma severity, endothelial cell counts (ECCs) and systemic factors identified in serum blood tests, were also examined.
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